IN USA MARKET

Diosmin is distributed in the U.S. as a dietary supplement. The FDA concluded that there was inadequate evidence on which to base an expectation of safety. A few companies that market diosmin supplements, have responded that diosmin can reasonably be expected to be safe on the basis of clinical trials, and has a long history of use in Europe. In the U.S., dietary supplements are regulated under Dietary Supplement Health and Education Act of 1994, which does not require proof of efficacy so long as no specific health claims are made.

Combined with Hesperidin

A branded name DiosVein is a patented bioflavonoid extract, it has been widely used in Europe for over 30 years (under the name Daflon). DiosVein is an extract comprised of 90% diosmin, and 10% hesperidin, in a highly bioavailable form. This bioflavonoid combination has been studied in over forty clinical trials and, although relatively new to America, has a 30-year track record of use in Europe. There it is regularly prescribed in preference to the traditional vein support, like horse chestnut and butcher’s broom.

Combined with HMC

Another Diosmin branded name,Diosmin-HMC,is a combination of the flavonoids diosmin and hesperidin methyl chalcone (HMC). Both flavonoids are derived from the citrus flavonoid hesperidin. HMC is a water-soluble, well-absorbed form of hesperidin.

Many experts believe flavonoids like hesperidin have a synergistic activity with vitamin C. Both diosmin and hesperidin can increase the strength of veins and capillaries. In addition, hesperidin can reduce histamine release from mast cells by strengthening the cell membrane (mast cells are blood cells that contain granules of histamine and other substances).

Diosmin HMC strengthens veins, promotes lymphatic drainage, and enhances circulation.