Diosmin availability

Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources. Diosmin was first isolated in 1925 from Scrophularia nodosa, and first introduced as a therapeutic agent in 1969 . Diosmin is considered to be a vascular-protecting agent used to help improving chronic venous insufficiency (CVI), haemorrhoids, lymphedema, and varicose veins . As a flavonoid, diosmin also exhibits anti-inflammatory, freeradical scavenging, and antimutagenic properties.

However, commercial quantity is not available from natural plant, but obtained from the flavonoid hesperidin which largely exhibits in citurs species fruits. Even in today’s European pharmacopeia, diosmin is defined directly as ‘ Substance obtained through iodine-assisted oxidation of (hesperidin) of natural origin.